In wxPython, you can set the style of a text control by using the wx.TextCtrl widget and applying styles at the time of its creation. You specify styles through a combination of style flags and, optionally, by setting the font or color properties. When creating a wx.TextCtrl, you can pass various style flags such as wx.TE_MULTILINE for a multi-line text control, wx.TE_READONLY for a read-only text control, and wx.TE_PASSWORD for password fields, among others.