Persistent caching in Golang can be achieved using various techniques such as using in-memory cache libraries like Gcache or implementing a custom solution using file-based or database-based storage. To implement persistent caching, first, define a struct to hold the cached data and a struct to manage the cache. Next, create functions to add, update, delete, and retrieve data from the cache. Use a file or database to store the cached data so that it can survive server restarts.